Adult pilocytic astrocytomas: clinical features and molecular analysis
نویسندگان
چکیده
منابع مشابه
Adult pilocytic astrocytomas: clinical features and molecular analysis.
BACKGROUND Adult pilocytic astrocytomas (PAs) are rare and have an aggressive clinical course compared with pediatric patients. Constitutive Ras/RAF/MAPK signaling appears to be an important oncogenic event in sporadic PA. We evaluated clinical data and molecular profiles of adult PAs at our institution. METHODS We identified 127 adult PAs in our institutional database. Cases with available t...
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Thirty-seven cases of juvenile pilocytic astrocytoma were reviewed retrospectively to determine their CT and MR characteristics. All cases occurred in pediatric patients, except for one in a young adult. There was a propensity for tumors to be located around the third and fourth ventricles. On CT the tumors were all sharply demarcated and smoothly marginated and rarely had associated edema. The...
متن کاملBenign cerebellar pilocytic astrocytomas in children.
AIM Cerebellar astrocytomas are benign tumors of the central nervous system. They represent 10% of all pediatric intracranial brain tumors and 30% of all pediatric posterior fossa tumors especially in the first two decades of life. MATERIAL AND METHODS We reviewed the medical records of patients; age at the time of surgery, pre- and post operative magnetic resonance imaging (MRI), localisatio...
متن کاملTenascin-C expression relates to clinicopathological features in pilocytic and diffuse astrocytomas.
AIMS Tenascin-C (TN-C) is an extracellular matrix brain glycoprotein for which conflicting in vitro and in vivo results are reported in the literature dealing with its involvement in astrocytoma aggressiveness, in particular astrocytoma invasion. In view of these conflicting results and the lack of data available on low-grade astrocytomas, the present study focuses on pilocytic World Health Org...
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BACKGROUND The aim of our study was to differentiate between cerebellar pilocytic astrocytomas and grade II ependymomas on the basis of their diffusion properties. PATIENTS AND METHODS The study prospectively included 12 patients with pilocytic astrocytomas and 5 with ependymomas. Apparent diffusion coefficients (ADC) were compared between tumour types. RESULTS ADC values were significantly...
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ژورنال
عنوان ژورنال: Neuro-Oncology
سال: 2014
ISSN: 1523-5866,1522-8517
DOI: 10.1093/neuonc/not246